To strengthen our team, we are offering a Ph.D. position in computational biology or bioinformaticsWe are looking for a computational biology / bioinformatics Ph.
D. student to process and analyze next-generation sequencing data to understand the functional contributions of the non-coding genome in the cardiovascular system.
About the lab
We bridge computational and experimental strategies to understand the functional contributions of the non-coding genome, such as regulatory DNA elements and long non-coding RNAs (lncRNAs) in the cardiovascular system.
We aim to understand the impact of epigenetic changes on heart function and explain why there is a gender bias for cardio-vascular disease.
More specifically, we will use mouse models and patient-derived samples to study the impact of epigenetic changes on female X chromosome inactivation and genomic imprinting.
Furthermore, we aim to elucidate relevant therapeutic candidates and new non-coding regulatory regions-based disease mechanisms that may form the basis of new therapies.
About the institute
The Institute of Pharmacology and Toxicology (IPT) is part of the Medical Faculty of the Technical University of Munich (TUM), one of the leading universities in the European Union.
The institute's research focuses on non-coding RNAs, their control of cardiac gene expression, and the effects of their therapeutic manipulation in cardiac disease.
The institute's state-of-the-art research facility includes a fully equipped mouse cardiac phenotyping lab, a viral vector core, and the entire experimental pipeline for next-generation sequencing from tissue or single-cells, including FACS-based cell separation.
Furthermore, the IPT coordinates and receives funding from the DFG Collaborative Research Center TRR267 "Non-coding RNA in the Cardiovascular System" and is the Munich partner site of the German Center for Cardiovascular Research (DZHK).
The outstanding infrastructure and experience present in the institute provide an ideal environment for a project to succeed.