Department of Bioloy/Chemistry
Universität Osnabrück
Osnabrück, DE
vor 4 Tg.

The section of Molecular Cell Biophysics in the Department of Biology / Chemistry at the University of Osnabrueck invites applications for the position of a

Research Assistant (m / f / d) (Ph.D. student level)

Salary level E 13 TV-L, 65 %)

starting as soon as possible. The position is limited for a period of three years.

Your responsibilities :

  • To elucidate the mechanisms of action of Gasdermin proteins during cell death. Gasdermins are the final executors of pyroptosis, a highly inflammatory form of regulated cell death, which has implications in infectious and inflammatory diseases and their clinical outcome.
  • Gasdermins induce pyroptosis by permeabilising the cell plasma membrane and inducing the release of inflammatory cytokines in the extracellular medium.

    In this project the candidate will investigate the mechanism of assembly of Gasdermin pore formation by the use of single molecule fluorescence microscopy and atomic force microscopy.

  • Purification, labelling and characterization of Gasdermin proteins and mutants.
  • Reconstitution of Gasdermin proteins in biological membranes.
  • Application of biophysical, molecular biological, and microscopic methods.
  • Application and analysis of single molecule and structural techniques.
  • Collaboration within the Collaborative Research Center 944 Physiology and dynamics of microcompartments .
  • The successful candidate will have the opportunity to work towards a PhD.
  • Required qualifications :

  • The candidate must hold an university degree (M.Sc. or diploma) in Biology, Biochemistry, or a related field.
  • Sound knowledge in biochemical, molecular biological and biophysical methods.
  • Practical experience in biochemical and molecular biological techniques.
  • Excellent command in written and spoken English.
  • Structured working approach and efficient working attitude.
  • Strong ability at trouble shooting.
  • The candidate is highly motivated and communicative.
  • Desirable qualifications :

  • Knowledge in membrane biophysics and structural biology.
  • Experience in protein purification.
  • Basic programming knowledge.
  • Ability to work in a team and good social skills.
  • We offer :

  • An exciting and highly topical research project.
  • Integration into the Collaborative Research Center 944 Physiology and dynamics of cellular microcompartments and its integrated education and funding programmes.
  • Integration in the Center of Cellular Nanoanalytics Osnabrueck CellNanOs and access to its facilities.
  • Collaboration in an interdisciplinary and international research team whose work focusses on understanding the dynamic molecular mechanisms of membrane proteins by advanced biophysical tools and single molecule microscopy techniques.
  • Osnabrück University has been certified as a family-friendly university committed to helping working / studying parents and carers balance their family and work life.

    The university aspires to ensure equal opportunities for men and women and strives to work towards a gender balance in schools or departments where new appointments are made.

    If equally qualified candidates apply, preference will be given to those with special needs.

    Please send your application (including a letter of motivation, CV, publication list, copies of certificates, as well as names and contact details of 3 referees) as one PDF file via Email to.

    Application deadline is September 1th 2019.

    For further information, please contact Jun. Prof. Dr. Katia Cosentino (email : ).

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